º» ¿¬±¸½Ç¿¡¼´Â,
ºÐÀÚ¼¼Æ÷ »ý¹°ÇÐÀû, Àü±â»ý¸®ÇÐ, »ýÈÇÐÀû ±â¹ý°ú ´õºÒ¾î
±¹³»¿¡¼ ÃÖÃÊ·Î µµÀÔµÈ ÃÊ°íÇØ»óµµ Çö¹Ì°æ (Super-resolution microscope) À̹Ì¡ ±â¹ý,
±×¸®°í ÃÖ±Ù Àü ¼¼°èÀûÀ¸·Î ÁÖ¸ñ¹Þ°í ÀÖ´Â ³úÁ¶Á÷ Åõ¸íÈ ¹× ¿°»ö±â¹ý µî À» È°¿ëÇÏ¿©
½Å°æ°è ½Ã³À½ºÀü¼¼Æ÷ (presynaptic cells)¿¡¼ÀÇ ½Å°æÀü´Þ¹°Áú ºÐºñ ±âÀÛ ¹× ½Ã³À½º Çü¼º±âÀÛ
½Ã³À½ºÈļ¼Æ÷(postsynaptic cells)ÀÇ ±¸Á¶º¯ÀÌ¿¡ µû¸¥ ½Å°æ±â´ÉÀÇ º¯È
½Å°æ¼¼Æ÷°£ÀÇ ½ÅÈ£Àü´Þü°è±¸Ãà°ú ½Å°æ°è ³×Æ®¿öÅ©Çü¼ºÀ» ¿¬±¸ÇÏ°í, À̸¦ ÅëÇÏ¿©
´Ù¾çÇÑ ½Å°æ°èÁúȯ (¾ËÃ÷ÇÏÀ̸Ӻ´, ¿ì¿ïÁõ, ´Ù¿î½Åµå·Ò, ÀÚÆóÁõµî)ÀÇ ½Å°æ¼¼Æ÷»ý¹°ÇÐÀû ±âÀüÀ» ±Ô¸íÇÔÀ¸·Î¼
½Å°æ°è ±â´É ¹× °¡¼Ò¼ºÀÇ ¿ø¸®Å½±¸ ¹× ¿¬°ü ½Å°æÁ¤½ÅÁúȯġ·á¸¦ À§ÇÑ ÀÌ·ÐÀûÀÎ Åä´ë¸¦ ±¸ÃàÇÏ°íÀÚ ÇÕ´Ï´Ù.
º» ½ÇÇè½ÇÀº ÇöÀç ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ÀÇ°úÇаü 3Ãþ¿¡ À§Ä¡ÇÏ°í ÀÖÀ¸¸ç
ÀÇ»ý¸í°úÇаü³» ÃÖ÷´Ü Çö¹Ì°æ¼³ºñ¸¦ °®Ãá ¹ÙÀÌ¿À¸ÞµðÄà À̹Ì¡¼¾Å͸¦ ¿î¿µ ÁßÀÔ´Ï´Ù´Ù.
¾Æ·¡ 3°¡Áö °úÁ¤À¸·Î ÀÔÇÐÁö¿øÀÌ °¡´ÉÇÕ´Ï´Ù.
¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ÀÇ°úÇаú (¹Ú»ç/¼®¹ÚÅëÇÕ)
¼¿ï´ëÇб³ ³ú°úÇÐÇùµ¿°úÁ¤ (¼®»ç/¹Ú»ç/¼®¹ÚÅëÇÕ)
¼¿ï´ëÇб³ À¯Àü°øÇÐÇùµ¿°úÁ¤(¼®»ç/¹Ú»ç/¼®¹ÚÅëÇÕ)
ÀÚ¼¼ÇÑ »çÇ×Àº ÀÇ°úÇаú ȨÆäÀÌÁö http://biomed.snu.ac.kr ¸¦ Âü°íÇØÁÖ¼¼¿ä
³ú°úÇÐ ¿¬±¸¿¡ ¶æÀÌ ÀÖ¾î ´ëÇпø ÁøÇÐÀ» °í¹ÎÇÏ´Â ºÐµéÀº ºÎ´ã°®Áö ¸¶½Ã°í ¹®ÀÇÁÖ¼¼¿ä!
½ÇÇè½Ç ȨÆäÀÌÁö http://biomed.snu.ac.kr/research/nfi/
¹®ÀÇ ¹× Áö¿ø ¸ÞÀÏ : 201522047@snu.ac.kr
<¿¬±¸½Ç ÃֽŠ³í¹® ¸ñ·Ï>
Impairment of Release Site Clearance within the Active Zone by Reduced SCAMP5 Expression Causes Short-Term Depression of Synaptic Release.
Park Daehun, Lee Unghwi, Cho Eunji, Zhao Haiyan, Kim Jung Ah, Lee Byoung Ju, Regan Philip, Ho Won-Kyung, Cho Kwangwook, Chang Sunghoe
Cell Rep 2018 3;22:3339-3350
Activation of CaMKIV by soluble amyloid-¥â1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis.
Park Daehun, Na Myeongsu, Kim Jung Ah, Lee Unghwi, Cho Eunji, Jang Mirye, Chang Sunghoe
Sci Signal 2017 7;10
Endosome-mediated endocytic mechanism replenishes the majority of synaptic vesicles at mature CNS synapses in an activity-dependent manner.
Park Joohyun, Cho Oh Yeon, Kim Jung Ah, Chang Sunghoe
Sci Rep 2016 Aug;6:31807
nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology.
Lee Sang-Eun, Kim Yoonju, Han Jeong-Kyu, Park Hoyong, Lee Unghwi, Na Myeongsu, Jeong Soomin, Chung ChiHye, Cestra Gianluca, Chang Sunghoe
Proc. Natl. Acad. Sci. U.S.A. 2016 06;113:6749-54
Ãâó : °í·Á´ëÇб³ °íÆĽº 2024-03-29 13:48:32: