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Apoptosis :


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¿äÁò ¸é¿ªÇп¡ °ü½ÉÀÌ ¸¹¾Æ¼­ ÀÚÅõ¸® ½Ã°£À» ³»¾î °øºÎÇÏ°í ÀÖ½À´Ï´Ù. (ºñ »ý¸í°úÇÐ/°øÇÐ Àü°øÀÚ)

T-¼¼Æ÷ °°Àº °æ¿ì¿¡´Â Treg (Helper T cell,CD4+)¿Í Cytotoxic T-cell (CD8+) ÀÖ½À´Ï´Ù.
Èï¹Ì·Î¿î »ç½ÇÀ» µ¡ºÙÀÌÀÚ¸é, Treg (Helper Tcell)ÀÌ ²À ÁÁÀº Àϸ¸ ÇÏ´Â°Ç ¾Æ´Ï¶ø´Ï´Ù. ÃÖ±Ù¿¡ Cancer immunology°¡ ÇÖÇÏ´Ù°í µé¾ú´Âµ¥ Treg cellÀÌ ¸» ±×´ë·Î T cellÀÇ functionÀ» regulateÇÏ¿© T-cell activation¿¡ negative signaling ¹× exhaustionÀ» ÁÖ¾î ¾Ï¼¼Æ÷ÀÇ T-cell evasionÀ» ÃËÁøÇÑ´Ù°í ÇÕ´Ï´Ù. Èï¹Ì·ÓÁö ¾Ê³ª¿ä?¤¾¤¾ ¿©±â¼­ Virus - Infected Cell°ú °ü·ÃÇÏ¿© ³ª¿Ô´Âµ¥ ÀÌ ºÎºÐÀº »ç½Ç ¿¹Àü¿¡ ¸¹ÀÌ ´Ù·ç¾ú´ø°É·Î ¾Ë°í ÀÖ¾î Àú Infected CellÀ» Cancer cell·Î ¹Ù²Ù¸é Á»´õ Èï¹Ì·Î¿î ¸¸È­°¡ µÇÁö ¾ÊÀ»±î »ý°¢ÇÕ´Ï´Ù.

µ¡ºÙ¿©, cancer microenvironment¿¡´Â Tcell »Ó¸¸ ¾Æ´Ï¶ó macrophage, neutrophiles, pericytes µî ´Ù¾çÇÑ differentiated cells µéÀÌ Á¸ÀçÇÏ¸ç ±× ¼¿µé ¶ÇÇÑ ´Ù¾çÇÑ signaling molecules À» ³»»Õ°Å³ª surface¿¡ ƯÁ¤ protein/protein receptor¸¦ ¹ßÇöÇÏ¿© Cancer cellÀÇ evasionÀ» µ½ÁÒ. ¿¹¸¦µé¾î, Cancer Cell¿¡´Â PDL1 À̶ó´Â Receptor°¡ Àִµ¥ ±× Receptor°¡ T-cellÀÇ PD1(?) °ú ¸¸³ª¸é T CellÀÌ Á¦´ë·Î ¿µÇâÀ» ¸ø ³¢Ä¡ÁÒ. ÀÌ·± °æ¿ì°¡ ¹Ù·Î À§¿¡ º¸ÀÌ´Â Killer T-cellÀÌ Infected cell (e.g. Cancer cell)À» Á×ÀÌÁö ¸øÇÏ´Â °æ¿ì°¡ µÇ´Â°ÅÁÒ.

µ¡ºÙ¿©, ÀÌ·¯ÇÑ PDL1/PDL ȤÀº CTL4 (¼³¸í ¾ÈÇÔ) µîÀ» ¾Æ¿ï·¯ checkpoint ¶ó°í Çϴµ¥ ÃÖ±Ù Æ®·»µå´Â ÀÌ·¯ÇÑ checkpoint blockade¸¦ ¸¸µé¾î T-cellÀÇ ExhaustionÀ» ¸·°í º¸´Ù È¿À²ÀûÀ¸·Î ¾Ï¼¼Æ÷¸¦ Ä¡À¯ ÇÑ´Ù°í ÇÕ´Ï´Ù ¤¾¤¾ °Å±â¿¡ ¿äÁò ´õ ÇÖÇÑ°Å´Â CART cell À» ÅëÇØ Á÷Á¢ ¾Ï¼¼Æ÷ÀÇ antigenÀ» bindingÇÏ´Â antibody¸¦ T-cell¿¡ ºÙ¿©¼­ °ø°ÝÇÏ´Â ¹æ¹ýÀÔ´Ï´Ù.

¾èÀº Áö½ÄÀÌ¿´Áö¸¸ ÀÌ ±ÛÀ» º¸´Â ´©±º°¡°¡ Cancer Immunology¿¡ ´ëÇؼ­ Á¶±ÝÀÌ¶óµµ ¹è¿ì´Â°Ô ÀÖÀ¸¸é ¹Ù¶ø´Ï´Ù ¤¾¤¾

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4/ Apoptosis
Apoptosis¿Í °ü·ÃÇÏ´Ï ¶Ç Àç¹Ì³­ ¿¡ÇǼҵ尡 »ý°¢³ª³×¿ä ¤¾¤¾ ÃÖ±Ù¿¡ ¾Ï Ä¡À¯ ¹æ¹ý¿¡µµ Apoptosis¸¦ ÀÌ¿ëÇÑ selective killing hypothesis °¡ ÇÖÇÏ´Ù°í ÇÕ´Ï´Ù. Áï, ¾î¶² cancer cellµéÀº apoptotic pathway gene upregulationÀ» ÇÏ¿© apoptotic signaling molecule (¿¹¸¦ µé¾î, Trail, H2O2 signaling, Caspase-9 cleavage, BCl/Bax oligomerization, release of cytochromeC)µîÀ» Á־ »ý°¢º¸´Ù cancer cellµéÀÌ Àß Á×Áö ¾Ê´Â´Ù°í ÇÕ´Ï´Ù (¿¹¸¦ µé¾î lung cancer cells). ¹Ý´ë·Î ¶È°°Àº ¾çÀÇ perturbationÀ» ÁÖ¾ú´Âµ¥ colon cancer °°Àº °æ¿ì´Â ´õ Àß Á×´Â´Ù°í ³ª¿Ô½À´Ï´Ù. ÀÌ·¯ÇÑ selectivity¸¦ ÀÌ¿ëÇÏ¿© apoptotic mediated cancer killing °ü·ÃÇÏ¿© ¿äÁò ¸¹Àº »ç¶÷µéÀÌ ¿¬±¸ÇÑ´Ù°í ÇÕ´Ï´Ù. ÀÌ¿Í µ¿½Ã¿¡ Apoptosis´Â Cancer cellµé¿¡°Ô¸¸ Áß¿äÇÑ°Ô ¾Æ´Ï¶ó ¿ì¸® ÀÏ»ó»ýÈ°¿¡µµ Áß¿äÇÕ´Ï´Ù. ±× ÀÌÀ¯´Â ¿ì¸® ¸ö gut villia µµ ¸Å 3ÀÏ Á¤µµ¿¡ ´Ù Á×°í ´Ù½Ã Å¾´Ï´Ù. ¼ÕÅé, ¸Ó¸®Ä«¶ô, skin cellsµéµµ ÀÌ¿Í °°Àº ÀÌÀ¯°í¿ä. ¹Ù·Î cellµéÀÌ programmed death ÇÏ´Â°Ô apoptosisÀ̸ç ÀÌ·¯ÇÑ apoptosis°¡ ÀÖ¾î¾ß ¿ì¸® ¼¼Æ÷µéÀÌ unlimited grow¸¦ ÇÏÁö ¾Ê´Â´Ù°í ÇÕ´Ï´Ù. ÀÌ·¯ÇÑ ÀÌÀ¯·Î apoptosisµµ ÀϹÝÀûÀÎ function¿¡ ÀÖ¾î ±²ÀåÈ÷ Áß¿äÇÑ ¿ªÇÒÀ» ÇÑ´Ù°í ÇÕ´Ï´Ù. ¤¾¤¾ :


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