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´ñ±Û 12
À͸í
2019-12-15 03:31:00
4/ Apoptosis
Apoptosis¿Í °ü·ÃÇÏ´Ï ¶Ç Àç¹Ì³ ¿¡ÇǼҵ尡 »ý°¢³ª³×¿ä ¤¾¤¾ ÃÖ±Ù¿¡ ¾Ï Ä¡À¯ ¹æ¹ý¿¡µµ Apoptosis¸¦ ÀÌ¿ëÇÑ selective killing hypothesis °¡ ÇÖÇÏ´Ù°í ÇÕ´Ï´Ù. Áï, ¾î¶² cancer cellµéÀº apoptotic pathway gene upregulationÀ» ÇÏ¿© apoptotic signaling molecule (¿¹¸¦ µé¾î, Trail, H2O2 signaling, Caspase-9 cleavage, BCl/Bax oligomerization, release of cytochromeC)µîÀ» Á־ »ý°¢º¸´Ù cancer cellµéÀÌ Àß Á×Áö ¾Ê´Â´Ù°í ÇÕ´Ï´Ù (¿¹¸¦ µé¾î lung cancer cells). ¹Ý´ë·Î ¶È°°Àº ¾çÀÇ perturbationÀ» ÁÖ¾ú´Âµ¥ colon cancer °°Àº °æ¿ì´Â ´õ Àß Á×´Â´Ù°í ³ª¿Ô½À´Ï´Ù. ÀÌ·¯ÇÑ selectivity¸¦ ÀÌ¿ëÇÏ¿© apoptotic mediated cancer killing °ü·ÃÇÏ¿© ¿äÁò ¸¹Àº »ç¶÷µéÀÌ ¿¬±¸ÇÑ´Ù°í ÇÕ´Ï´Ù. ÀÌ¿Í µ¿½Ã¿¡ Apoptosis´Â Cancer cellµé¿¡°Ô¸¸ Áß¿äÇÑ°Ô ¾Æ´Ï¶ó ¿ì¸® ÀÏ»ó»ýÈ°¿¡µµ Áß¿äÇÕ´Ï´Ù. ±× ÀÌÀ¯´Â ¿ì¸® ¸ö gut villia µµ ¸Å 3ÀÏ Á¤µµ¿¡ ´Ù Á×°í ´Ù½Ã Å¾´Ï´Ù. ¼ÕÅé, ¸Ó¸®Ä«¶ô, skin cellsµéµµ ÀÌ¿Í °°Àº ÀÌÀ¯°í¿ä. ¹Ù·Î cellµéÀÌ programmed death ÇÏ´Â°Ô apoptosisÀ̸ç ÀÌ·¯ÇÑ apoptosis°¡ ÀÖ¾î¾ß ¿ì¸® ¼¼Æ÷µéÀÌ unlimited grow¸¦ ÇÏÁö ¾Ê´Â´Ù°í ÇÕ´Ï´Ù. ÀÌ·¯ÇÑ ÀÌÀ¯·Î apoptosisµµ ÀϹÝÀûÀÎ function¿¡ ÀÖ¾î ±²ÀåÈ÷ Áß¿äÇÑ ¿ªÇÒÀ» ÇÑ´Ù°í ÇÕ´Ï´Ù. ¤¾¤¾ :
ÀÛ¼ºÀÚ¿¡°Ô °æ°í³ª °µî(ÀÌ¿ëÁ¤Áö) óºÐÀÌ ÇÊ¿äÇÑ°¡¿ä? ¸ÅÀÏ ¹«ÀÛÀ§·Î ¼±Á¤µÇ´Â °íÆĽº ¹è½É¿øµé¿¡°Ô ÆÇ°áÀ» ¸Ã±é´Ï´Ù.
(ÁÖÀÇ) ½Å°í ³»¿ë¿¡ ¿å¼³,Æø¾ð µî ºÒÇÊ¿äÇÑ ±ÛÀ» ¾²½Ã¸é []´ÔÀÌ °µîµË´Ï´Ù. »çÀ¯¸¸ °£´ÜÈ÷, °¨Á¤À» ¹èÁ¦ÇÏ°í ½áÁÖ¼¼¿ä.
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